smoking research studies

smoking research studies

Smoking Research Studies

Welcome! This website will provide you with information on some research studies that are available to smokers. Please select the link below able to see information about our current studies for which you might qualify.

We are currently running studies for smokers who are NOT planning to quit soon.

First Received: October 14, 2011 | Last Updated: December 20, 2011

Phase: N/A | Start Date: July 2011

Overall Status: Completed | Estimated Enrollment: 88

The purpose of this study is to develop a fit-for-purpose biochemical verification tool that can be used to detect concomitant use of a few (less than 5) conventional cigarettes.

Full Title of Study: “A Single-centre, Dose Titration Study in Healthy Volunteers (Smokers and Non-smokers) to Evaluate the Capacity of 2-cyanoethylmercapturic Acid (CEMA) to Detect Low Level of Cigarette Smoking Exposure”

  • Study Type : Interventional
  • Study Design
    • Allocation : Non-Randomized
    • Intervention Model : Parallel Assignment
    • Primary Purpose : Basic Science
    • Masking : None (Open Label)
  • Study Primary Completion Date : November 2011

This study will be performed in two parts. The first part, Part A, is a dose titration study in healthy smokers with incremental cigarette consumption performed in confinement. The second part, Part B, is an observational study on healthy non-smokers in an ambulatory setting

PART A (smokers only)

A screening visit will be conducted within 4 weeks prior to admission to the investigational site. The 8-day confinement period consists of the admission day (Day1), 1 day ad-libitum smoking (Day0), 3 days of smoking abstinence (Day1-3), 2-day exposure period smoking 2 and 4 cigarettes (Day4-5), and the day of discharge (Day6) followed by a 7-day safety follow-up period. Urine collection will be performed for each subject from Day0 to Day5 in 4 intervals.

PART B (non-smokers)

Screening visit will be conducted within 4 weeks prior to the ambulatory Visit 1 (collection of 24-hour urine and spot urine) to the investigational site. The minimum interval between the screening and Visit 1 is of 7 days.

  • Other: Part A
    • Smoking abstinence, smoking 2 and 4 cigarettes
  • No Intervention: Part B. Healthy Caucasian adult non-smokers
    • Non-smokers
  • Experimental: Part A.Healthy Caucasian adult smokers
    • No product will be investigated in this study. Smokers will smoke their own conventional cigarettes only.

Clinical Trial Outcome Measures

  • Levels of CEMA, a biomarker of exposure to acrylonitrile, in 24-hour urine of smokers smoking 2 or 4 conventional cigarettes
    • Time Frame : After smoking 2 or 4 conventional cigarettes, within 24 hours
    • To demonstrate that CEMA, used as a urinary biomarker, can identify subjects who have smoked 4 or less conventional cigarettes
  • Levels of CEMA in 24-hour urine, carboxyhaemoglobin (COHb) in blood and carbon monoxide in exhaled breath of smokers smoking 2 or 4 conventional cigarettes
    • Time Frame : After smoking 2 or 4 conventional cigarettes, within 24 hours
    • To evaluate the ability of CEMA to detect conventional cigarette use in comparison to COHb and exhaled carbon monoxide
  • Levels of CEMA, a biomarker of exposure to acrylonitrile, in 24-hour and spot urine of non-smokers
    • Time Frame : 24 hours
    • To evaluate the correlation between the levels of CEMA in 24-hour urine and in spot urine in non-smokers

Participating in This Clinical Trial

Common criteria to smokers and non-smokers

1. Subject is able to understand the information provided in the Subject Information sheet and Informed Consent Form (ICF)

2. Subject has signed the ICF

3. Subject of Caucasian origin

4. Aged from 23 to 55 years

5. Having acceptable health conditions as judged by the Investigator at the screening visit based on clinical laboratory parameters (clinical biochemistry, urine analysis and standard haematology), spirometry, serology, urine drug screen, vital signs, physical examination, ECG, and medical history

Specific to smokers

6. Current smoker based on self-reporting who smoke 5 to 15 commercially available non-mentholated conventional cigarettes (no brand restrictions) with a maximum tar yield of 10 mg (ISO method, as labelled on the cigarette package) smoking at least for the last 3 consecutive years. The smoking status will be verified at screening based on a urinary cotinine test (cotinine ≥200ng/ml)

7. Subject is willing to smoke according to the smoking regimen of the study

Specific to non-smokers

8. Non-smoker based on self-reporting who have not used any tobacco or nicotine containing product including commercially available cigarettes, hand-rolled cigarettes, cigars, pipes, snuff, electronic cigarettes, similar devices, and nicotine replacement therapy within the last 12 months. The non-smoking status of the subject will be verified at screening based on a urinary cotinine test (cotinine <200ng/ml)

Common criteria to smokers and non-smokers

1. As per judgement of the Investigator, any subject who cannot participate in the study for any reason (e.g., medical, psychiatric and/or social reason)

2. Any clinically relevant gastrointestinal, renal, hepatic, neurological, haematological, endocrine, oncological, urological, immunological and cardiovascular diseases or any other condition including clinically significant abnormal laboratory parameters that, in the opinion of the Investigator, could jeopardise the safety of the subject or impact the validity of the study results

3. Lung cancer, upper respiratory tract cancers, chronic respiratory diseases or any other clinically significant pulmonary diseases according to the judgement of the Investigator

4. Any medical conditions requiring smoking cessation (e.g., recent acute cardiovascular event, diabetes mellitus, Chronic Obstructive Pulmonary disease)

5. Subject with body mass index < 18.5 or ≥ 30 kg/m2

6. As per judgement of the Investigator, medical conditions which require or will require in the course of the study a medical intervention (e.g., start of treatment, surgery, hospitalisation) which may interfere with the study participation and/or study results

7. Donation or receipt of whole blood or blood products within 3 months prior to the screening visit

8. Participation in any clinical studies within 3 months before the screening visit

9. Current or former employee of the tobacco industry, or of their first-degree relatives (parent, sibling, child)

10. Employee of the investigational site or any other parties involved in the study or of their first-degree relatives (parent, sibling, child)

11. Enrolled in the same study at a different time (i.e., each subject can be in the study population only once)

12. Subject who is legally incompetent, physically or mentality incapable of giving consent (e.g., emergency situation, under guardianship, subject in a social or sanitary establishment, prisoners or subject who are involuntarily incarcerated)

13. Positive alcohol test and/or history of alcohol abuse that could interfere with subject's participation in study

14. Positive urine drug tests (amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine and opiates)

15. Positive serology test (HbsAg, HCV, HIV)

Specific to smokers

16. Subject who has used any nicotine-containing products other than commercially available cigarettes (either a tobacco-based product or nicotine-replacement therapy) as well as electronic cigarettes and similar devices within 1 month prior to the screening visit

Additionally, women of childbearing potential must be excluded if:

17. Subject is pregnant (does not have negative pregnancy tests at screening and at admission) or breastfeeding

18. Subject does not agree to use an acceptable method of effective contraception: intrauterine device, intrauterine system, established use of oral/injectable/implantable/transdermal hormonal methods, barrier methods of contraception (condoms, occlusive caps) with spermicidal foam/gel/film/suppository, vasectomised partner or true abstinence (periodic abstinence and withdrawal are not effective methods) from screening until the end of the safety follow-up period

Gender Eligibility : All

Minimum Age : 23 Years

Maximum Age : 55 Years

Are Healthy Volunteers Accepted : Accepts Healthy Volunteers

A research study tests or evaluates treatments—such as new or current medications, behavior treatments, medical equipment, clinical therapies, procedures, or programs—to determine if they are safe and effective.

If you are looking for a way to stop smoking, participating in a research study may be right for you. People in research studies can receive new treatments before they reach the public. You may also help other smokers by contributing to research that could lead to new treatment options in the future.

There are countless smoking cessation research studies going on around the world to help determine the best, most effective ways to help people stop smoking and stay quit. A number of the studies being run in the United States are funded by the National Institutes of Health ( NIH ) and carried out by researchers outside of NIH , usually at universities or medical schools.

Where Can I Learn More About Research Studies?

To learn more about smoking research studies currently recruiting around the world, visit the clinicaltrials.gov database.

Development of the smoking cessation app “Smiling instead of Smoking”

If you smoke cigarettes on some days (but not daily), and are interested in using a smoking cessation app to help you do so, you may be eligible to participate in our research study. We’ll provide smoking cessation support via our newly developed smartphone app and will compensate you for your time (up to $434). To set up a phone-screen call and get started with this study, please call 617-724-3129 or email [email protected] Please note that our app currently is only available for Android smartphones.

Six-Month Outcomes of a Mobile Smoking Cessation Program

Want to quit smoking? Not even? Either way, we’d like to talk. Be among the first to use a new program designed to help people learn about their smoking and—if they want—quit. During this six-month research study, participants will give breath samples with a personal sensor and use a smartphone app to interact with a personal coach, do brief games and activities, and track their smoking.

The study is entirely remote (no office visits or clinic appointments). Participants will earn up to $315 for completing the study, with compensation every one to four weeks, after completing short questionnaires.

This study is open to adult smokers aged 18-65 in the continental United States who own and use a smartphone.

Want to cut down on smoking before completely quitting? The Cut2Quit Study can help you with that!

Researchers at UCSF are developing a program that allows smokers to track and gradually reduce their smoking before quitting for good.

If you are 18 years and older, regularly smoke cigarettes, and use an iPhone, you may be eligible to participate in the Cut2Quit Study. Study participants will receive nominal cash incentives for completing surveys and a free gift valued at $125!

For more information and to sign up for the study, please visit: ​http://cut2quit.eurekaplatform.org/NCI

Multimodal Neuroimaging Genetic Biomarkers of Nicotine Addiction Severity

Study Location: Baltimore, MD (Local Recruitment)

Quitting smoking is hard. Let us help you through it. If you are 18-60 years old and ready to quit smoking, we need you for a research study on nicotine dependence at the National Institute on Drug Abuse in Baltimore. The study’s treatment plan is customized to your individual needs and includes free nicotine replacement combined with one-on-one counseling. This is a program that offers a research/treatment combination.

  • Earn up to $1690 for completing the study
  • Receive compensation after each study visit
  • Receive an MRI image of your brain on a t-shirt
  • Evening and weekend study appointments available

We want you to succeed. Call today to see if you qualify.

Study Location: In-person visits in the Los Angeles area

Are you ready to quit smoking? The Addictions Research Laboratory in the UCLA Department of Psychology is looking for smokers, between the ages of 21 and 65 who drink alcohol regularly, to participate in a research study. Participants will receive 14 weeks of FREE treatment with effective smoking cessation medication and will be asked to attend study visits at the UCLA campus in Westwood.

Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers

Study Location: In-person visits in the Chicago area

This research study offers two different forms of counseling, along with an FDA-approved medication or matched placebo, designed to help people who have experienced depressed mood or loss of interest to quit smoking.

As part of the study, participants receive eight sessions of free individual smoking cessation treatment delivered by trained therapists, along with 12 weeks of varenicline (Chantix) or placebo. Participants may earn up to $205 for completing all aspects of the study.

If you are interested in learning more about the study and seeing if you are eligible to participate, please call 1-877-236-7487, email our study team at [email protected], or visit http://tinyurl.com/smoking-depression.

Extended Varenicline Treatment for Cigarette Smoking Among Cancer Patients

Study Location: In-person visits in the Chicago area

Quitting smoking is hard, especially for people who are fighting cancer, but Northwestern University's and University of Pennsylvania's Quit for Health program can help. Quit for Health is now offering a clinical research study funded by the National Cancer Institute that is evaluating a new smoking cessation intervention tailored to cancer patients and survivors.

Eligible smokers will receive seven sessions of smoking cessation counseling and receive varenicline, a U.S. Food and Drug Administration (FDA)-approved smoking cessation medication – all at no charge. Participants receive $10 for each completed session and an additional $10 for travel.

If you are over the age of 18, diagnosed with cancer within the last five years, and interested in learning more about the study and our specialized smoking cessation treatment, please call (1-877-236-7487) or email Michael Maloney [email protected]

Study location: University of California, Irvine

Are you looking to quit smoking, but need help? Apply for the Tweet2Quit program today! You will receive a complimentary 8-week supply of nicotine patches & gum, as well as the opportunity to earn up to $60 by completing short surveys. Our program can help motivate you to quit smoking using the power of a peer-based support group, all from the convenience of your phone. This study is open to smokers aged 21 to 59 in the continental United States who plan to quit smoking. You must also have a mobile phone with unlimited texting, use some sort of social media regularly, and be willing to tweet with your quit smoking group daily. For further info please click: http://tweet2quit.merage.uci.edu/

Study location: Nationwide

Department of Psychiatry at Duke University is conducting a research study on how you take Chantix® (varenicline) medication to quit smoking. You will receive electronic pill bottles called “MEMS Cap” to use while you take your medication. You will need to have an Android or iOS smartphone. If you have recently started taking or planning to take Chantix® (varenicline) to quit smoking, then make the most of your quit attempt by joining the mSMART Smoking Study.

To learn more about the study or volunteer to participate, please contact:

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Вы не можете посетить текущую страницу по причине:

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